COZYME Action brings together a leading group of researchers with a combination of skills and experience spanning computational enzyme design, enzyme engineering and enzyme production. The COZYME collaborative network comprises a mix of research-leading groups from different parts of Europe, including four Inclusiveness Target Countries and is based on an appropriate gender balance, with ~50% of senior research positions being held by women in this action. Moreover, several of the research groups involved are represented by Early Career Investigators. Mentoring and networking activities which support active and efficient transfer of know-how and knowledge among members will be implemented. COZYME will scientifically lift the European field of computational protein engineering to the next level.